5 edition of Epithelial calcium and phosphate transport: Molecular and cellular aspects found in the catalog.
Written in English
|The Physical Object|
|Number of Pages||392|
Molecular mechanisms of proximal tubule transport Transport in the proximal tubule is slightly different in the early and late portions of this segment. Early on, sodium is resorbed together with phosphate or organic solutes such as amino acids, glucose, and citrate on a variety of solute-specific symporters (represented by a single generic. Phosphate-dependent luminal ATP metabolism regulates transcellular calcium transport in intestinal epithelial cells. FASEB J 32, – Crossref, Medline, Google Scholar; Weissmuller T, Campbell EL, Rosenberger P, .
Calcium metabolism 1. Calcium Metabolism - Dr. Chintan 2. Calcium Extracellular calcium ion concentration is determined by, interplay of calcium absorption from the intestine, renal excretion of calcium, and bone uptake and release of calcium, regulated by the hormones - vitamin D, parathyroid hormone (PTH), and calcitonin Phosphate homeostasis closely associated with Calcium . The role of the kidney in calcium homeostasis has been reshaped from a classic view in which the kidney was regulated by systemic calcitropic hormones such as vitamin D3 or parathyroid hormone to an organ actively taking part in the regulation of calcium handling. With the identification of the intrinsic renal calcium-sensing receptor feedback system, the regulation of paracellular calcium.
Rickets and hyperparathyroidism caused by a defective vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)2 vitamin D [1,25(OH)2D3] action on calcium homeostasis. We assessed the rate of serum 45Ca accumulation within 10 min of oral gavage . The calcium transport system does not require sodium and in loops from the distal small intestine calcium transport is enhanced by reduction of sodium concentration in the medium. It is postulated that there is a common sodium-requiring system which is necessary for the linkage of metabolic energy to glucose, amino acid, and inorganic phosphate.
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Epithelial Calcium and Phosphate Transport: Molecular and Cellular Aspects Progress in Clinical and Biological Research: Volume Edited by Felix Bronner and Meinrad Peterlik Alan R. Liss; New York, xxiii + pages. f This contains the.
Get this from a library. Epithelial calcium and phosphate transport: molecular and cellular aspects: proceedings of the Second International Workshop on Calcium and Phosphate Across Biomembranes, held in Vienna, Austria, March[Felix Bronner; Meinrad Peterlik;]. In conclusion, the effect of STC1 on calcium transport in intestinal epithelia is due to, at least in part, its negative regulation of the epithelial channels TRPV5/6 that mediate calcium influx.
View. Abstract Many new insights into the molecular mechanisms of intestinal absorption of calcium, phosphate, and magnesium have been made over the past decade. These include the identification, cloning, and characterization of transmembrane proteins responsible for the absorption of all three of these nutrient molecules.
The proteins identified for uptake of Ca 2 +. T1 - Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium. AU - Kiela, Pawel R. AU - Ghishan, Fayez K. PY - /3/ Y1 - /3/ N2 - Many new insights into the molecular mechanisms of intestinal absorption of calcium, phosphate, and magnesium have been made over the past by: 6.
Studies with isolated membrane vesicles F. Bronner, M. Peterlik, Epithelial Calcium and Phosphate Transport: Molecular and Cellular Aspects () Liss New York H. Murer, P. Gmaj, Transport studies in plasma membrane vesicles isolated from renal cortex Kidney Int () C.
Roche, D. Bellaton, D. Pansu, and F. Bronner, Simultaneous induction of CaBP and active calcium transport in rat duodenum by 1,dihydroxyvitamin D in: “Epithelial Calcium and Phosphate Transport: Molecular and 76–1lular Aspects”, F.
Bronner and M. Peterlik, eds., Alan R. Liss, New York (). Google Scholar. Calcium is recognized as a critical element for normal homeostasis and is a major constituent of bone.
An average 70 kg adult human has 1 kg of body calcium, with more than 99% of calcium found in bones and teeth in the form of calcium hydroxyapatite (Ca 10 [PO 4] 6 [OH] 2).Bone tissue serves as a reservoir and a source of calcium for critical metabolic needs.
Mechanisms and regulation of epithelial phosphate transport in ruminants: approaches in comparative physiology. Pflügers Archiv - European Journal of Physiology, Vol.Issue. 1, p. functional and molecular aspects. HN & Kimberg, DV () Cellular and paracellular calcium transport in rat ileum.
Carafoli E () Molecular, mechanistic, and functional aspects of the plasma membrane calcium pump. In: Bronner F, Peterlik M (eds) Epithelial calcium and phosphate transport: molecular and cellular aspects.
Alan R Liss, New York, pp 13–18 Google Scholar. Over the past 25 years, successive cloning of SLC34A1, SLC34A2 and SLC34A3, which encode the sodium-dependent inorganic phosphate (Pi). Protein kinases constitute one of the largest gene families and control many aspects of cellular life.
calcium–phosphate transport complex that provides these necessary nutrients to the. A classic nephrology reference for over 25years, Seldin and Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology.
In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework.
Prog Clin Biol Res. ; Epithelial calcium and phosphate transport. Molecular and cellular aspects. Proceedings of the Second International Workshop on Calcium and Phosphate Across Biomembranes. It has been known since the mid-nineteenth century that after blood clots the resulting serum possesses a substance that constricts vascular smooth muscle so as to increase vascular tone.
Around the turn of this century, platelets were identified as the source of this substance. In the late s, Rapport and collaborators  isolated, purified and identified this “tonic” substance in.
Ca 2+ is absorbed across intestinal epithelial monolayers via transcellular and paracellular pathways, and an active form of vitamin D 3, 1α,dihydroxyvitamin D 3 [1α,25(OH) 2 D 3], is known to promote intestinal Ca 2+ absorption. However, the molecules driving the paracellular Ca 2+ absorption and its vitamin D dependency remain obscure.
Because the tight junction. Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these ions.
Gastrointestinal absorption is balanced by renal excretion. When body stores of these ions decline significantly, gastrointestinal absorption, bone resorption, and renal tubular reabsorption.
Phosphate is present in the body in three ionic forms: H 2 PO 4−, HPO42, and PO43−. The most common form is HPO42−HPO42−. Bone and teeth bind up 85 percent of the body’s phosphate as part of calcium-phosphate salts.
Phosphate is found in phospholipids, such as those that make up the cell membrane, and in ATP, nucleotides, and buffers. Collins, J.F. and Ghishan, F.K. () “Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate and Magnesium”. For Physiology of the Gastrointestinal Tract, 4th Edition.
Academic Press. The crucial role played by calcium as a cellular messenger has become increasingly evident, as has the recognition that cells spend much energy in maintaining the cytosolic concentration of this cation both constant and low.
It is thought they do this to avoid precipitating phosphate. Calcium is one of the most important second messengers and its intracellular signaling regulates many aspects of cell physiology. Calcium ions, like phosphate ions, are highly charged and thus are able to alter protein conformation upon binding; thereby they constitute key factors in signal transduction.
One of the most common calcium-binding structural motifs is the EF .Nanoparticles exhibit potential as drug carriers in biomedicine due to their high surface-to-volume ratio that allows for facile drug loading. Nanosized drug delivery systems have been proposed for the delivery of biologics facilitating their transport across epithelial layers and maintaining their stability against proteolytic degradation.
Here, we capitalize on a nanomanufacturing process.When calcium availability is high, this pathway responsible for the bulk of calcium absorption, due to the very short time available for active transport in the duodenum. Phosphorus Phosphate is transported into the epithelial cells by contransport with sodium, and expression of this (or these) transporters is enhanced by vitamin D.